| Date | Location | Result | Â |
| Dec 29, 2010  | Washington, DC   | Maryland 51, East Carolina 20  | Box score |
| Nov 26, 2010  | Greenville, N.C.   | SMU 45, East Carolina 38  | Box score |
| Nov 20, 2010  | Houston, Texas   | Rice 62, East Carolina 38  | Box score |
| Nov 11, 2010  | Birmingham, Ala.   | East Carolina 54, UAB 42  | Box score |
| Nov 06, 2010  | Greenville, N.C.   | NAVY 76, East Carolina 35  | Box score |
| Oct 30, 2010  | Orlando, Fla.   | UCF 49, East Carolina 35  | Box score |
| Oct 23, 2010  | Greenville, N.C.   | East Carolina 37, Marshall 10  | Box score |
| Oct 16, 2010  | Greenville, N.C.   | East Carolina 33, N.C. State 27  | Box score |
| Oct 09, 2010  | Hattiesburg, Miss.   | East Carolina 44, Southern Miss 43  | Box score |
| Oct 02, 2010  | Chapel Hill, NC   | North Carolina 42, East Carolina 17  | Box score |
| Sep 18, 2010  | Blacksburg, Va.   | Virginia Tech 49, East Carolina 27  | Box score |
| Sep 11, 2010  | Greenville, N.C.   | East Carolina 49, Memphis 27  | Box score |
| Sep 5, 2010   | Greenville, N.C.   | East Carolina 51, Tulsa 49  | Box score |
