| 08/19/2021 | at Old Dominion | L | 1-2 | 0-1-0, 0-0-0 | 0-0-0 | 459 | Peyton Godbey (1) (Carsen Parker)
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| 08/22/2021 | vs VMI | W | 4-0 | 1-1-0, 0-0-0 | 0-0-0 | 247 | Haley McWhirter (1) (Holly Schlagel) Samantha Moxie (1) (Sierra Lowery) Grace Doran (1) (Samantha Moxie) Brooke Burzynski (1)
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| 08/26/2021 | vs South Carolina | L | 1-3 | 1-2-0, 0-0-0 | 0-0-0 | 862 | Sierra Lowery (1)
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| 08/29/2021 | at High Point | W | 2-1 | 2-2-0, 0-0-0 | 0-0-0 | 424 | Tori Riggs (1) Maycie McDougal (1)
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| 09/02/2021 | vs Campbell | W | 1-0 | 3-2-0, 0-0-0 | 0-0-0 | 314 | Kim Sanford (1) (Abby Sowa)
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| 09/05/2021 | vs VCU | W | 2-0 | 4-2-0, 0-0-0 | 0-0-0 | 262 | Kim Sanford (2) (Morgan Dewey) Peyton Godbey (2) (Lindsey Aiken)
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| 09/09/2021 | at Duke | L | 0-5 | 4-3-0, 0-0-0 | 0-0-0 | 603 | Â |
| 09/12/2021 | at William & Mary | L | 0-1 | 4-4-0, 0-0-0 | 0-0-0 | 191 | Â |
| 09/16/2021 | at South Fla. | L | 2-3 | 4-5-0, 0-1-0 | 0-1-0 | 554 | Haley McWhirter (2) Tori Riggs (2) (Samantha Moxie)
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| 09/19/2021 | at James Madison | L | 0-1 | 4-6-0, 0-1-0 | 0-1-0 | 192 | Â |
| 09/23/2021 | vs SMU | L | 0-2 | 4-7-0, 0-2-0 | 0-2-0 | 347 | Â |
| 09/30/2021 | at Cincinnati | T | 1-1 | 4-7-1, 0-2-1 | 0-2-1 | 401 | Haley McWhirter (3) (Lexi Moore)
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| 10/03/2021 | vs Old Dominion | W | 1-0 | 5-7-1, 0-2-1 | 0-2-1 | 257 | Brooke Burzynski (2) (Samantha Moxie , Morgan Dewey)
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| 10/07/2021 | vs Temple | W | 2-1 | 6-7-1, 1-2-1 | 1-2-1 | 257 | Samantha Moxie (2) (Morgan Dewey) Tori Riggs (3) (Sydney Schnell)
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| 10/10/2021 | at Houston | W | 1-0 | 7-7-1, 2-2-1 | 2-2-1 | 209 | Haley McWhirter (4) (Annabelle Abbott , Holly Schlagel)
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| 10/17/2021 | at Tulsa | T | 2-2 | 7-7-2, 2-2-2 | 2-2-2 | 194 | Haley McWhirter (5) (Tori Riggs) Tori Riggs (4) (Haley McWhirter)
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| 10/21/2021 | vs UCF | L | 0-2 | 7-8-2, 2-3-2 | 2-3-2 | 582 | Â |
| 10/24/2021 | vs Memphis | W | 2-1 | 8-8-2, 3-3-2 | 3-3-2 | 472 | Annabelle Abbott (1) (Abby Sowa) Haley McWhirter (6) (Samantha Moxie)
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| 10/31/2021 | at SMU | L | 1-2 | 8-9-2, 3-3-2 | 3-3-2 | 330 | Morgan Dewey (1)
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